Author

Mark C Leake

Biophysical Sciences Institute, Durham University, Durham, DH1 3LE, United Kingdom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Adam JM WollmaniD· 1 shared Adam Wollman· 1 shared Akihiro Kusumi· 1 shared Alex Hargreaves· 1 shared Charlotte Fournier· 1 shared Djamila Ouret· 1 shared Dominic Alderson· 1 shared Isabel Llorente-Garcia· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Adam JM WollmanORCID

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Author profile →

2 papers

Recent·Most cited

MaCADEMIA: a software toolbox for single-molecule fluorescence image quantification

Dominic Alderson, Zoe Catchpole, Katrina Crompton, Katherine Sanders, Sophia Johnson, Kirsty Smith, John Packer, Kate S Harris, Josana Rodriguez, Mark C Leake, Adam JM Wollman

MaCADEMIA is a MATLAB toolbox for single-molecule fluorescence image analysis, providing accurate quantification of molecular properties in living cells.

bioRxiv · Nov 2, 2026 · PreprintBioinformatics

EGF signaling in bowel carcinoma cells utilizes higher order architectures of EGFR and HER2

Adam Wollman, Charlotte Fournier, Isabel Llorente-Garcia, Oliver Harriman, Alex Hargreaves, Sviatlana Shashkova, Peng Zhou, Djamila Ouret, Jenny Wilding, Ta-Chun Liu, Akihiro Kusumi, Walter F Bodmer, Mark C Leake

This study uses single-molecule imaging to show that EGF signaling in carcinoma cells involves EGFR and HER2 clusters with increased stoichiometry after EGF activation.

bioRxiv · Jul 11, 2020 · PreprintBiophysics