Mark Robertson-Tessi

The Goldilocks Window of Personalized Chemotherapy: An Immune Perspective

This study uses mathematical modeling to show that optimal chemotherapy scheduling must balance tumor reduction and immune preservation to maximize treatment efficacy.

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

The paper models how timing of aromatase inhibitor and immune checkpoint inhibitor therapies affects tumor burden and metastatic potential in hormone receptor positive breast cancer.

Non-linear tumor-immune interactions arising from spatial metabolic heterogeneity

This study uses a hybrid mathematical model to show that immune response to tumors depends on spatial metabolic heterogeneity and varies across tumor growth stages.

Exploiting Homeostatic Repopulation to Increase DC Vaccine Efficacy in Multiple Myeloma

This paper tests a dendritic cell vaccine in multiple myeloma patients before and after AHCT to improve outcomes and uses a model to guide future trials.

Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

This paper explores the genotype-phenotype map using molecular switches to show how robustness and persistence emerge, explaining bet-hedging strategies and their implications for treatment resistance.