Alexander RA Anderson

This study uses mathematical modeling to show that optimal chemotherapy scheduling must balance tumor reduction and immune preservation to maximize treatment efficacy.

The paper develops a mathematical model to estimate cancer stem cell fractions in tumors using tumor size measurements and linear regression, without requiring detailed microscopic data.

This paper explores the genotype-phenotype map using molecular switches to show how robustness and persistence emerge, explaining bet-hedging strategies and their implications for treatment resistance.

This paper uses a computational model to show that spatial organization of blood vessels in tumors affects radiation response, with varying correlations depending on vessel density.

This paper develops a Markov Chain model to analyze antibiotic resistance emergence in E. coli and shows that drug sequencing can probabilistically steer populations away from resistance.