Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy
Benedikt Grünewald, Jonathan Wickel, Nina Hahn, Franziska Hörhold, Hanna Rupp, Ha-Yeun Chung, Holger Haselmann, Anja S. Strauss, Lars Schmidl, Nina Hempel, Lena Grünewald, Anja Urbach, Michael Bauer, Klaus V. Toyka, Markus Blaess, , Christian Geis
This study identifies synaptic pathomechanisms of sepsis-associated encephalopathy and demonstrates that targeted rescue of synaptic plasticity can improve cognitive decline in a mouse model.
bioRxiv · Mar 4, 2021 · PreprintNeuroscience