Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia
Anand Pathak, Scott L. Brincat, Yihan Xiong, Haris Organtzidis, Mason Protter, Vincent Du, Helmut H. Strey, Lilianne Rivka Mujica-Parodi, Earl K. Miller, Richard Granger
The paper uses a mechanistic model to simulate propofol's effects on brain circuits, identifying a dose-dependent biomarker confirmed in empirical data.
bioRxiv · Oct 9, 2026 · PreprintNeuroscience