Homeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Ekaterini Platanitis, Duygu Demiroz, Christophe Capelle, Anja Schneller, Markus Hartl, Thomas Gossenreiter, Mathias Müller, Maria Novatchkova, Thomas Decker
The paper shows that interferons switch macrophages from resting to gene expression by altering ISGF3 subunit composition, with IFNγ inducing full ISGF3 complex formation on DNA.
bioRxiv · Jul 25, 2018 · PreprintImmunology