Liver transplant rejection features memory cell priming, spatially differentiated networks and novel drug targets.
Mylarappa Ningappa, Chethan Ashokkumar, Divya Murali, Dhivyaa Rajasundaram, Brandon W. Higgs, William McDonald, Lori A. Schmitt, Liang Zhang, Ansuman Chattopadhyay, Matt Kane, Patrick Murphy, Kyle A Soltys, George Vincent Mazariegos, Shakti Gupta, Upendra K. Kar, , Rakesh K. Sindhi
The paper identifies molecular and spatial features of early liver transplant rejection, including primed T-cells, immune synapse activation, and novel drug targets like proteasomal and HSP90 inhibitors.
bioRxiv · Feb 4, 2025 · PreprintImmunology