Structural modelling and functional analysis support lipid binding by the dimeric E. coli DedA protein YqjA
Thomas J. Paige, Junxi Chen, Aline Le Roy, Connor D. D. Sampson, Benjamin F Cooper, Matthew Batson, Hollie L. Scarsbrook, Lucy R. Forrest, Georgia L. Isom, Caroline Mas, Vanessa Leone, Christopher Mulligan
The paper identifies a lipid-binding site in the dimeric E. coli DedA protein YqjA through structural modeling and functional assays, showing lipid binding enhances thermal stability and is essential for function.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry