Georgia L. Isom

This study identifies YhdP as an envelope-spanning phospholipid-binding bridge that interacts with DedD to facilitate phospholipid transport in E. coli.

This study develops molecular glue-like degraders that target TEM β-lactamases for degradation by DegP, showing improved synergy with piperacillin against resistant E. coli.

This study shows how a bacterial Rhesus transporter modifies a conserved ammonium pore to function as a reversible nitrogen valve through specific residue changes.

The paper identifies a lipid-binding site in the dimeric E. coli DedA protein YqjA through structural modeling and functional assays, showing lipid binding enhances thermal stability and is essential for function.

This study determines the structure and function of NeRh50, a Rh-family protein in Nitrosomonas europaea, revealing lipid associations and divergent ammonium transport properties compared to canonical Amt proteins.

This study shows YdbL modulates YdbH-YnbE bridge formation in E. coli to maintain outer membrane homeostasis by interacting with YnbE and preventing its degradation.

This study identifies sphingolipid transport proteins in Caulobacter crescentus that function similarly to LPS transport proteins, revealing a shared transport mechanism.

This study identifies YbaA as a new ciprofloxacin-binding protein in E. coli using AfBPP and validates its interaction through genetic and biophysical assays.

This study identifies YhdP as a phospholipid transporter spanning the bacterial cell envelope, using AlphaFold, electron microscopy, and simulations to show its structure and function.