Author

Matthew Brownd

University of Arkansas at Fayetteville

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 1 Approach:deep learning· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:simulation· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Mahmoud MoradiiD· 3 shared Ashkan FakharzadehiD· 1 shared Ehsaneh KhodadadiiD· 1 shared Hope WoodsiD· 1 shared Parth ChaturvediiD· 1 shared Stephanie M. SauveiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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3 shared papersBiophysics

Mahmoud MoradiORCID

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3 papers

Recent·Most cited

Predicting Binding Affinities for the Binding Domain of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Isoforms Using Free-Energy Perturbation

Matthew Brownd, Stephanie M. Sauve, Hope Woods, Mahmoud Moradi

The paper uses free-energy perturbation to calculate binding affinities of cAMP to HCN isoforms 1-4 CNBDs, revealing differences in channel activation sensitivity.

bioRxiv · Mar 6, 2026 · PreprintBiophysics

An Investigation of the Conformational Dynamics of ABC Exporter PCAT1 using Microsecond-Level MD Simulations

Matthew Brownd, Ehsaneh Khodadadi, Mahmoud Moradi

This study uses microsecond MD simulations and FEP to analyze nucleotide binding and conformational dynamics of PCAT1, revealing Mg2+ and substrate-dependent stabilization mechanisms.

bioRxiv · Mar 6, 2026 · PreprintBiophysics

Characterizing the Conformational Dynamics of an Intrinsically Disordered Localization Sequence

Matthew Brownd, Parth Chaturvedi, Ashkan Fakharzadeh, Mahmoud Moradi

This study examines how single-residue substitutions in a mitochondrial localization peptide affect its conformational dynamics, revealing that sequence changes can bias structural ensembles and influence targeting efficiency.

bioRxiv · Mar 6, 2026 · PreprintBiophysics