A scalable human neuron model of Alzheimer's disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction
Joanna Lipka, Xiwei Shan, Qiao Zhang, Przemysław Dutka, Lilian Phu, Matthew C Johnson, Timothy J. Wendorff, Max Adrian, Anne Biton, Dawei Sun, Meena Choi, John G. Moffat, Alexis L. Rohou, Alessandro Ori, Céline Eidenschenk, , Jasvinder K. Atwal
This paper develops scalable human neuron models of Alzheimer's disease to reveal mechanisms linking Tau fibrillization to synaptic dysfunction and identifies therapeutic targets.
bioRxiv · Sep 12, 2026 · PreprintCell Biology