Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration
Aditi Bagade, Rebecca Miller, Joshua T. Dearborn, Katherine Basore, Brock Summers, Bradley Readnour, Matthew Koelling, Jennifer O'Shea, Elizabeth Wright, Dhruva D. Dhavale, Paul T. Kotzbauer
The paper shows that injecting amplified Lewy body dementia fibrils into mice leads to fibril accumulation with LBD structure and neurodegeneration.
bioRxiv · Oct 13, 2026 · PreprintNeuroscience