Tissue and cellular spatiotemporal dynamics in colon aging
Aidan C. Daly, Francesco Cambuli, Tarmo Äijö, Britta Lötstedt, Nemanja Despot Marjanovic, Sara Fernandez, Olena Kuksenko, Matthew Smith-Erb, Daniel Domovic, Nicholas Van Wittenberghe, Eugene Drokhlyansky, Gabriel Kenneth Griffin, Hemali P. Phatnani, Richard Bonneau, Aviv Regev, Sanja Vicković
This study creates a spatial and cellular atlas of the colon across age groups using spatial transcriptomics and single nucleus RNA-seq, identifying age-related molecular gradients and multicellular programs.
Nature Biotechnology · Oct 22, 2025Peer-reviewedSystems Biology