A noncanonical polyamine from bacteria antagonizes animal mitochondrial function
Kelsie M. Nauta, Darrick R. Gates, Matthew Weiland, Marco E. Mechan Llontop, Xiao Wang, Kim Nguyen, Christine N. Isaguirre, Megan Genjdar, Ryan D. Sheldon, Connie M. Krawczyk, Nicholas O. Burton
This study identifies N1-APA, a noncanonical polyamine produced by bacteria, as a bioactive metabolite that antagonizes animal mitochondrial function and macrophage activation.
bioRxiv · Apr 29, 2024 · PreprintPhysiology