Systems BiologyBiophysical JournalPeer-reviewed
Systems-level Consequences of Low RAF Abundance for EGFR-ERK Signaling
Sung Hyun Lee, Paul J. Myers, Max C. Mendrzycki…·Matthew J. Lazzara
The paper develops computational models of the EGFR-ERK pathway to show that low RAF abundance creates signaling bottlenecks and stochastic dynamics, affecting ERK activation and RAS-RAF interactions in cancer cells.
1 citation