Leslie M. Loew

The paper uses mesoscale simulations to estimate 2D bimolecular rate constants for membrane-tethered reactions, which can parameterize cell-scale signaling models.

The paper develops computational models of the EGFR-ERK pathway to show that low RAF abundance creates signaling bottlenecks and stochastic dynamics, affecting ERK activation and RAS-RAF interactions in cancer cells.

The paper derives a solubility product model for biomolecular phase boundaries, showing it accounts for variable stoichiometry and soluble oligomers, revealing curvature and re-entrant behavior in phase boundaries.

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.

The paper introduces a Python package for simulating and analyzing multivalent biomolecular clusters using stochastic simulations.

This study investigates hyperexcitability in iPSC-derived neurons from Dup15q patients, identifying mechanisms like delayed action potential maturation and KCNQ2 channel disruption.

The paper validates the focal specificity of transcranial functional photoacoustic voltage-sensitive dye imaging in rat hippocampus by correlating NMDA-evoked neural activity with glutamate release and EEG signals.

This paper demonstrates the use of functional photoacoustic imaging with a near-infrared voltage-sensitive dye to record in vivo neural activity in rats without craniotomy, showing distinguishable responses in seizure models.