Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndrome
Nikolas Layer, Peter Müller, Maya Ayash, Friederike Pfeiffer, Meret Saile, Fabian Klopfer, Stefano Iavarone, Andrea Santuy, Petra Fallier‐Becker, Ulrike B. S. Hedrich, Holger Lerche, Henner Koch, Thomas V. Wuttke
This study uses single-cell RNA sequencing in a Dravet syndrome mouse model to identify early transcriptomic changes and axonopathy in interneurons during epileptogenesis.
bioRxiv · Oct 4, 2023 · PreprintNeuroscience