Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination
Rumi Habib, Shahlo O. Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh, Colby J. Agostino, Nicholas J. Tursi, Kirsten J. Sowers, Jinwei Huang, Ryan S. Roark, Mansi Purwar, Younghoon Park, Kasirajan Ayyanathan, Hui Li, , Daniel W. Kulp
The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.
Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedImmunology