Peroxisome protein import deficiency causes heart failure in mouse and human
Julia Hofhuis, Malte Tiburcy, Yelena Hartmann, Kristina Bersch, Ahmed Wagdi, Óscar Gutiérrez-Gutiérrez, Richard Solano, Leonie Thiele, Maya Walper, Mona Göbel, Wolfgang Hübner, Branimir Berečić, Marilu Casini, Petros Tirilomis, Andreas Unger, , Sven Thoms
This study shows that peroxisome dysfunction in mice and engineered human myocardium leads to heart failure through metabolic impairment and disrupted cellular respiration.
bioRxiv · Oct 13, 2025 · PreprintCell Biology