Discovery of an NRAS isoform and activation-state selective macrocyclic peptide
Kenneth K. Hallenbeck, Yunpeng Zhou, Hubert B. Josien, Songnian Lin, Aileen Soriano, Mayhood Todd, Jaclyn Robustelli, Xiaomei Chai, My Sam Mansueto, Gireedhar Venkatachalam, Ryan E. Loy, Peng‐Hsun Chase Chen, Huifang Yao, Haihong Zhou, Elsa Beyer Krall, , S. Adrian Saldanha
The paper identifies a macrocyclic peptide that selectively binds NRAS with isoform and activation-state specificity, but lacks membrane permeability and functional inhibition.
bioRxiv · Jul 31, 2026 · PreprintCancer Biology