Liposomal DAGLβ Inhibitor Shows Substantial Antinociceptive Potency Mediated by AMPK in a Neuropathic Pain Mouse Models
Liam Babcock, Madeline Gunawardena, Payton E. Lowrey, Rudra Pangeni, Mckenzie Hall, M. Taylor, Saniya Chethan, Sara M Herz, Dayna A Adeso, Olivia L. Murtagh, Qingguo Xu, Ku‐Lung Hsu, Aron H. Lichtman
The paper demonstrates that liposomal DAGLβ inhibitor KT109 shows significantly higher antinociceptive potency in neuropathic pain models, mediated by AMPK activation.
bioRxiv · Oct 21, 2026 · PreprintPharmacology & Toxicology