Author

Mega Sidharta

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Alessandro EvangelistiiD· 2 shared Lorenz StuderiD· 2 shared Ting ZhouiD· 2 shared Youjun WuiD· 2 shared Aaron ZhongiD· 1 shared Adrienne Ann BoireiD· 1 shared Ahmed OsmaniD· 1 shared Alan Y. L. WongiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Alessandro EvangelistiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Decoding subtype development and function in human pluripotent stem cell-derived midbrain dopaminergic neurons

Donghe Yang, Sejoon Choi, Jinghua Piao, Alessandro Evangelisti, Zhe Yang, Vittoria Dickinson Bocchi, Shkurte Ademi Donohue, Nidia Claros, Johannes Jungverdorben, Mega Sidharta, Youjun Wu, Hilda Amalia Pasolli, Tae Wan Kim, Ting Zhou, David L. Sulzer, , Lorenz Studer

This study develops a method to derive and maintain specific subtypes of human midbrain dopaminergic neurons in vitro, revealing their functional and molecular characteristics and potential vulnerability in disease.

bioRxiv · Sep 24, 2026 · PreprintDevelopmental Biology

A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV

Philipp Niklas Ostermann, Youjun Wu, Scott A. Bowler, Samuel Martínez-Meza, Mohammad Adnan Siddiqui, David H. Meyer, Alberto M. Herrera, Brandon A. Sealy, Mega Sidharta, Kiran Ramnarine, Leslie Ann St. Bernard, Desiree Byrd, R. Brad Jones, Masahiro Yamashita, Douglas F. Nixon, , Teresa H. Evering

Direct reprogramming of skin fibroblasts into neurons reveals unique gene signatures indicative of HIV infection in the context of viral suppression.

JCI Insight · Nov 25, 2025Peer-reviewedNeuroscience

Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells

Youjun Wu, Aaron Zhong, Alessandro Evangelisti, Mega Sidharta, Danwei Huangfu, Lorenz Studer, Ting Zhou

This study develops a CRISPRa-based method to rapidly verify gene editing in human pluripotent stem cells without differentiation.

Stem Cell Reports · May 8, 2025Peer-reviewedCell Biology

Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges

Xinran Tong, Ján Remšík, Jeannette R. Brook, Boryana Petrova, Lele Xu, Minjun Li, Jenna Snyder, Kiana Chabot, Rachel Estrera, Isaiah Osei-Gyening, Ana Rita Nobre, Helen H. Wang, Ahmed Osman, Alan Y. L. Wong, Mega Sidharta, , Adrienne Ann Boire

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

bioRxiv · Oct 13, 2024 · PreprintCancer Biology