Ting Zhou

Timed binary WNT activity is sufficient to model the early human neural axis

This paper shows that timed WNT pulses can specify distinct neural domains in human pluripotent stem cells, enabling the generation of specific neuron and progenitor types.

Modeling human embryonic adrenogenesis in pluripotentstem cell-derived corticomedullar-like assembloids

This study develops a method to model human adrenal development using pluripotent stem cell-derived assembloids that recapitulate corticomedullar differentiation and function.

Decoding subtype development and function in human pluripotent stem cell-derived midbrain dopaminergic neurons

This study develops a method to derive and maintain specific subtypes of human midbrain dopaminergic neurons in vitro, revealing their functional and molecular characteristics and potential vulnerability in disease.

Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signaling

This paper presents a protocol to rapidly generate human oligodendrocytes from pluripotent stem cells using BMP and Notch signaling inhibition, achieving high purity and functional myelination.

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature

This study shows that inosine misincorporation into mRNA activates the integrated stress response and an innate immune gene expression signature, linking ITPase deficiency to cellular stress.

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 + T cells

The paper develops EliteMHCII, a high-throughput platform to identify MHC II epitopes and assess peptide binding affinity, showing high-affinity peptides correlate with strong CD4+ T cell responses.