Plate-based ISD-SPE enables dual proteome-secretome concentration-response profiling of TLR signalling in iPSC-derived macrophages
Chloe L. Tayler, Mengchun Li, Kerena Norris, Lee M. Booty, Rebecca Beveridge, Nicholas J. W. Rattray, Rachel E. Heap
This paper introduces a plate-based ISD-SPE workflow for integrated proteome and secretome analysis of TLR signaling in macrophages, showing improved reproducibility and scalability for drug discovery.
bioRxiv · Jul 21, 2026 · PreprintImmunology