Michael Anderson

Interpretable variant effect prediction from genomic foundation model embeddings

A low-rank covariance probe on Evo 2 embeddings predicts ClinVar pathogenicity across SNVs and indels, while annotation probes plus an LLM produce mechanistic hypotheses; scores released for 4.2 million variants.

A Cluster of Acidic Residues in the Cytoplasmic Domain of SARS-CoV-2 Spike is Required for Virion-Incorporation and Infectivity

This study identifies an acidic cluster motif in the SARS-CoV-2 Spike protein's cytoplasmic domain essential for virion incorporation and infectivity.

Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like Particle (SC2-VLP) infectivity

The paper shows electromagnetic waves at 2.5-3.5 GHz reduce SARS-CoV-2 VLP infectivity by altering Spike protein conformation.

ClinGen CDH1 specifications for the ACMG/AMP guidelines: improvement of germline variant clinical assertions and updated curation guidelines

The paper updates CDH1 variant curation guidelines to resolve conflicting interpretations and reduce variants of uncertain significance for clinical use.