A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice
Yuancheng Ryan Lu, Han Shen, Kathrin M Kajderowicz, 艾家和, Yi Hua Chen-Neumann, Yan Hu, Alexander Tyshkovskiy, Qiannuo Lou, Tianwei Dong, Louisa Grauvogel, Zhaoyi Chen, James C. Cameron, Ximeng Li, 新多朗 白濱, Michael Bligh, , Jonathan S. Weissman
The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.
bioRxiv · Sep 30, 2026 · PreprintGenetics