RNA-mediated MYC multimerization suppresses innate immune signaling
Leonie Uhl, Amel Aziba, Sinah Löbbert, Timothy J. Russell, Toshitha Kannan, Omkar Rajendra Valanju, Christina Schülein-Völk, Tim de Martines, Francisco Montesinos, Michael Bolz, Giacomo Cossa, Theresa Endres, Daniel Solvie, Bastian Krenz, Hans Michael Maric, , Martin Eilers
This study shows that MYC multimerization driven by RNA binding suppresses innate immune signaling by promoting exosome recruitment to R-loops and preventing immunogenic RNA accumulation.
bioRxiv · Dec 6, 2024 · PreprintMolecular Biology