Giacomo Cossa

This study shows that MYC multimerization driven by RNA binding suppresses innate immune signaling by promoting exosome recruitment to R-loops and preventing immunogenic RNA accumulation.

This study shows MYCN binds RNA and regulates transcript turnover, with its RNA-binding activity affecting transcription control through competition with DNA-binding.

The paper shows that NONO relocalizes to the nucleolus via diNARs to shield DNA breaks from aberrant transcripts, promoting repair.