Pharmacology & ToxicologybioRxivPreprint
Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance
Albert Hung, Xinru Wang, Michael Gao…·Eunhee Choi
This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.
DOI 10.64898/2026.05.04.722722