Phosphodiesterase type 1 regulates adenosine 2A receptor-associated cAMP signaling at the plasma membrane to increase myocardial contractility
Michael L. Fitch, Maria Alexandria Martins Goncalves, Mary H. Y. Tang, Evan D. Kelly, Emily C. Cheung, Purvaj Kandula, Emily Jones, Szymon Sornat, Orien Sun, Manuela Zaccolo, Matthew W. Kay, Grace K. Muller
This study shows PDE1 regulates A2AR-associated cAMP signaling at the sarcolemma to enhance myocardial contractility in healthy and failing hearts.
bioRxiv · Oct 3, 2025 · PreprintPhysiology