GPNMB enables lysosomal adaptation required for myelin clearance and nerve regeneration after peripheral nerve injury
Najwa Ouali Alami, Moh Panesar, Michael Obrecht, Thierry Doll, Ivan Osinnii, Gilles Sansig, Zacharias Thiel, Isabelle Claerr, Daniel J. Greenwood, Claudia Patiño, Laurent Klein, Daniela C. Ivan, E. Giorgetti, Christian Lambert, Georgios Kalamakis, , Michael Bidinosti
This study identifies GPNMB as a critical regulator of lysosomal function in macrophages, essential for myelin clearance and nerve regeneration after peripheral nerve injury.
bioRxiv · Oct 19, 2026 · PreprintNeuroscience