A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma
Shoval Miyara, Shachaf Frenkel, Avi Mayo, Philippe D. Gascard, Michael Strasser, David L. Gibbs, Eviatar Weizman, Isaac Shalom, Yaniv Stein, Deng Pan, Joseph A. Caruso, Veena Sangwan, Nicholas Bertos, Julie Bérubé, Sophie Camilleri‐Broët, , Uri Alon
The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.
bioRxiv · Aug 25, 2025 · PreprintCancer Biology