Yaniv Stein

The paper identifies a conserved inflammation-associated fibroblast state in Crohn's disease and ulcerative colitis linked to TCF21 loss and shows TCF21 restoration can suppress inflammatory mediators.

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

The U-method identifies robust biological markers by comparing expression probabilities across clusters, showing consistent marker detection across cancer datasets and spatial transcriptomics.

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

The paper shows cancer-associated fibroblasts suppress NK cell cytotoxicity by acting as decoys, leading to poor disease outcomes in breast cancer.