Mapping chromothripsis across human cancer cell lines reveals genome evolution and therapeutic vulnerabilities
Gil Leor, Tal Ben-Yishay, Adi V Tarrab, Yonatan Eliezer, Tom Winkler, Michal Goetz, Linoy Raz, Eli Reuveni, Ron Shamir A, Uri Ben‐David
This study maps chromothripsis in 1,646 human cancer cell lines, showing its conservation with tumors, higher prevalence, and therapeutic vulnerabilities to HDAC inhibitors.
bioRxiv · Oct 30, 2026 · PreprintCancer Biology