Tom Winkler

This study maps chromothripsis in 1,646 human cancer cell lines, showing its conservation with tumors, higher prevalence, and therapeutic vulnerabilities to HDAC inhibitors.

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

This study identifies Del17p as a biomarker for AURKB inhibition in breast cancer, showing increased sensitivity to AURKB inhibitors in Del17p tumors.

This study shows p53 inactivation is not universally linked to aneuploidy but is associated with increased chromosome loss in cancer.