Author

Mihoko Leon

Massachusetts Eye and Ear Infirmary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Eric A. PierceiD· 2 shared Qin LiuiD· 2 shared Scott H. Greenwald· 2 shared Andrea M. SartoriiD· 1 shared Anne M.J. VerstegeniD· 1 shared Benjamin P. KleinstiveriD· 1 shared Cassandra N. Seifert· 1 shared Daniel Navarro-Gomez· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Eric A. PierceORCID

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Author profile →

3 papers

Recent·Most cited

Descending Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Biased Control of Micturition

Nataliya Klymko, Andrea M. Sartori, Mihoko Leon, Cassandra N. Seifert, Richard Lee, John Mathai, Anne M.J. Verstegen

The paper identifies a specific neuronal population in Barrington's nucleus critical for urinary control and shows its sex-specific role in micturition.

bioRxiv · May 16, 2025 · PreprintNeuroscience

Ift172 conditional knockout mice exhibit rapid retinal degeneration and protein trafficking defects

Priya R Gupta, Nachiket D. Pendse, Scott H. Greenwald, Mihoko Leon, Qin Liu, Eric A. Pierce, Kinga M. Bujakowska

This study creates a mouse model of IFT172-associated retinal degeneration and shows that IFT172 depletion causes rapid retinal degeneration and protein trafficking defects.

Human Molecular Genetics · Apr 4, 2018Peer-reviewedGenetics

Allele-specific CRISPR/Cas9 genome editing of the single-base P23H mutation for rhodopsin associated dominant retinitis pigmentosa

Pingjuan Li, Benjamin P. Kleinstiver, Mihoko Leon, Michelle S. Prew, Daniel Navarro-Gomez, Scott H. Greenwald, Eric A. Pierce, J. Keith Joung, Qin Liu

This study demonstrates allele-specific CRISPR/Cas9 editing of the P23H mutation in Rho-P23H mice, reducing mutant allele expression and delaying photoreceptor degeneration.

The CRISPR Journal · Feb 1, 2018Peer-reviewedGenetics