Non-canonical EGFR signaling is essential for MAPK-mediated apical extrusion of epithelial cells
Paola Molina, Mikiyas Daniel, Jason Wang, Ian G. Macara
This study shows that non-canonical EGFR signaling, independent of ERK and AKT, is required for Ras-induced apical extrusion of epithelial cells through E-cadherin internalization.
bioRxiv · May 16, 2025 · PreprintCancer Biology