Million Veteran Program

A genomic-led strategy to anticipate drug safety effects

The paper uses Mendelian Randomization to predict adverse drug reactions by linking genetic variants to gene expression and protein abundance across large datasets.

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty

This study investigates genetic predictors of inpatient opioid exposure after knee or hip surgery using EHR and genotype data from 27,896 individuals across three ancestries, finding no genome-wide significant loci.

Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities

This study identifies ten genetic loci associated with dry eye disease and finds significant genetic correlations with several comorbidities.

Genome-wide association study meta-analysis brings monogenic hearing loss genes into the polygenic realm

This paper conducts a GWAS meta-analysis of sensorineural hearing loss, identifying 108 loci, including 54 novel genes, and shows substantial genetic overlap between cohorts despite differing phenotypes.

From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study

The paper develops a polygenic risk model for prostate cancer using VA data and validates it in external cohorts, showing its clinical utility in risk stratification.

Flexibly encoded genome-wide association study identifies novel nonadditive genetic risk variants for cardiometabolic traits

This paper introduces EDGE, a method to detect nonadditive genetic effects in GWAS, finding nonadditive patterns in over 52% of significant loci for coronary artery disease and body mass index.

Pharmacogenetic allele variant frequencies: An analysis of the VAs Million Veteran Program (MVP) as a representation of the diversity in US population.

The paper analyzes pharmacogenetic variant frequencies in the MVP dataset to represent US population diversity across different ancestries.

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

The paper identifies a missense variant in the MARC1 gene associated with protection against cirrhosis and lower liver enzyme and cholesterol levels.

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

This paper conducts GWAS on anxiety traits in the Million Veteran Program, identifying significant genetic loci and demonstrating genetic overlap with depression.