Heng Xu

This study identifies genetic loci associated with alcohol use disorder and consumption, finding distinct genetic architectures and variants with direct effects on AUD.

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.

The paper uses polygenic risk scores and phenome-wide association studies to examine pleiotropy in substance use disorders using a deeply phenotyped sample.

This study shows polygenic risk scores for substance use disorders predict substance use milestones and progression, with differences by sex and population group.

This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.

This paper applies MTAG to GWAS of substance use traits, identifying novel genetic loci and showing improved polygenic risk scores for four disorders.