Extracellular Vesicles-Mediated Crosstalk in Bone: miR-150-5p as a Mechanosensitive Inhibitor of Osteoclastogenesis
Mimma Maggio, Carolina Martins, R. Almasri, S R Petrousek, Mathieu Y. Brunet, L.A. Madden, Cansu Görgün, Tara Ní Néill, Conor Timothy Buckley, Lorraine O’Driscoll, David A. Hoey
This study identifies mechanically-activated osteocyte-derived extracellular vesicles and miR-150-5p as key regulators of osteoclastogenesis and potential therapeutic targets for skeletal diseases.
bioRxiv · Sep 8, 2025 · PreprintBioengineering