A Tonic Signaling Code Predicts CAR-T Cell Efficacy in Diffuse Midline Glioma
Emily Deng, Xiaowen Zhong, Dazhuan Eric Xin, Upendra Kumar Soni, Wenkun Ma, Xiao Huang, Mingjun Cai, Po-Yu Liang, Jun Bai, Qian Qin, Shreya V. Mishra, Ming Hu, Arman Esshaghi Bayat, Jiajie Diao, Mei Xin, , Q. Richard Lu
This study identifies tonic signaling as a key factor in CAR-T cell efficacy for diffuse midline glioma, showing that restrained tonic signaling improves therapeutic outcomes.
bioRxiv · Sep 29, 2025 · PreprintCancer Biology