TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons
Heeyoung An, Hye-Lan Lee, Doo‐Wan Cho, Jinpyo Hong, Hye Yeong Lee, Jung Moo Lee, SunYeong Choi, In‐Young Hwang, Junsung Woo, Jaekwang Lee, Mingu Park, Young‐Su Yang, Su-Cheol Han, Yoon Ha, Changjoon Justin Lee
This paper describes a method to convert reactive astrocytes into functional motor neurons with high efficiency and specificity using TRANsCre-DIONE, leading to improved motor recovery in spinal cord injury.
Experimental & Molecular Medicine · Sep 11, 2026Peer-reviewedNeuroscience