The common evolution of fungicide persistence in cryptococcosis patients
Yuyan Xie, Weixin Ke, Xin Fan, Heping Xu, Wenzhao Wang, Zhen Zeng, Na Zhang, Haoran Ma, Zhongjie Tang, Huawei Zhu, Lei Jiang, Bo Zhu, Guohui Shi, Sihan Yang, Minling Yu, , Linqi Wang
The paper identifies common evolutionary events leading to fungicide persistence in Cryptococcus neoformans clinical isolates and shows ACO2 deficiency as a key predictor of high persistence.
bioRxiv · Aug 26, 2026 · PreprintMicrobiology