Development of a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rational adjuvant selection
Miranda McCarty, Sergio A. Hernández, Jill Malfetano, Ana Carolina Leao, María José Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, María Elena Bottazzi, Utpal Pal, Klemen Strle, Wen‐Hsiang Chen, Yi‐Pin Lin
This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.
bioRxiv · Jan 11, 2026 · PreprintImmunology