Mitchell J. Bartlett

Dyskinesia induced by a dopamine 2 receptor-like agonist, but not a dopamine 1 receptor-like agonist, is blocked by sub-anesthetic ketamine

This study shows that sub-anesthetic ketamine reduces dyskinesia caused by D2R-like receptor agonists but not D1R-like receptor agonists in L-DOPA-primed rats.

The anti-dyskinetic and the anti-parkinsonian effects of sub-anesthetic ketamine are also present in female preclinical models

This study shows that sub-anesthetic ketamine reduces dyskinesia and improves motor function in female preclinical models of Parkinson's disease and L-DOPA-induced dyskinesia.