Moe Kitazawa

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin

This study shows that Resf1 is essential for placental development and trophoblast cell-specific heterochromatin configuration in mice, with loss of Resf1 leading to retroelement upregulation and developmental defects.

AGO2 slicing restrains RTL1 to prevent vascular defects and lethal neonatal muscle failure