Loss of Hnf1b in differentiated proximal tubule cells uncovers nephron segment plasticity
Zeinab Dehghani‐Ghobadi, Eunah Chung, Azadeh Haghighitalab, Mohammed Sayed, Christopher Ahn, Yueh‐Chiang Hu, Hee‐Woong Lim, Joo‐Seop Park
This study shows that HNF1B is essential for maintaining proximal tubule identity in mature kidney cells and prevents activation of alternative nephron segment programs.
bioRxiv · Aug 17, 2026 · PreprintDevelopmental Biology