Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42
Yu-Chou Tseng, Sophia G. Liva, Anees M. Dauki, Michael Sovic, Sally E. Henderson, Yi-Chiu Kuo, Jason A. Benedict, Samuel K. Kulp, Moray Campbell, Tanios Bekaii-Saab, Mitchell A. Phelps, Ching-Shih Chen, Christopher C. Coss
This study combines a SARM and HDAC inhibitor to improve anti-cachectic efficacy in a mouse model of cancer cachexia, showing significant improvements in bodyweight and muscle mass.
bioRxiv · Oct 5, 2018 · PreprintCancer Biology