GPR15 and CD38 define a subset of peripheral blood pathogenic effector Th2 cells associated with active eosinophilic esophagitis
Caitlin M. Burk, Duncan M. Morgan, Jonathan N. Glickman, Yamini V. Virkud, Emily Liao, Elizabeth G. Moseley, Karina Eva Canziani, Moumita Bhowmik, Jennifer C. Li, Tarun Keswani, Navneet Virk Hundal, Aubrey J. Katz, Qian Yuan, Sarita U. Patil, John Christopher Love, Wayne G. Shreffler
The paper identifies GPR15+ CD38+ peripheral blood Th2 cells associated with active eosinophilic esophagitis, showing potential as a non-invasive biomarker and suggesting new disease mechanisms.
bioRxiv · Nov 16, 2025 · PreprintImmunology