A combination of systemic mannitol administration and mannitol-modified polyester nanoparticles facilitate gene delivery to the brain through caveolae-mediated endocytosis
Betsy Reshma Gilbert, Chirag Miglani, Arundhati Karmakar, Muneesh Pal, Vysakh C. Chandran, Sarika Gupta, Asish Pal, Munia Ganguli
This paper demonstrates that combining mannitol-modified nanoparticles with systemic mannitol injection enables efficient gene delivery to the brain via caveolae-mediated endocytosis.
Molecular Therapy — Nucleic Acids · Feb 6, 2025Peer-reviewedBioengineering